基底细胞样乳腺癌中HIF-1α 及Glut-1 的表达及意义
| 作者: |
1周炳娟,
1陈红,
1马秋双,
1张金库,
1张楠,
1肖士卿,
2王国茹,
3马红普
1 河北省保定市第一中心医院 病理科，河北 保定 071000 2 河北省容城县医院 妇产科，河北 保定 071700 3 河北省高阳县医院 妇产科，河北 保定 071500 |
| 通讯: |
张金库
Email: zjkblk@sohu.com |
| DOI: | 10.3978/.10.3978/j.issn.1005-6947.2015.05.019 |
摘要
目的：探讨缺氧诱导因子1α（HIF-1α）及葡萄糖转运蛋白1（Glut-1）蛋白在基底细胞样乳腺癌（BLBC）中的表达及临床意义。方法： 采用免疫组化方法检测95 例BLBC 及其癌旁乳腺组织与708 例非BLBC 组织中HIF-1α 及Glut-1 蛋白的表达，分析两者表达与BLBC 临床病理因素的关系。结果：HIF-1α 及Glut-1 蛋白在BLBC 组织的阳性表达率均明显高于癌旁组织与非BLBC 组织（均P<0.05），两种蛋白的表达呈明显正相关（r=0.368，P<0.05）。结论：HIF-1α 和Glut-1 的表达在BLBC 组织中同时升高，两者可能共同参与了BLBC 的发生、发展，并可能作为评估BLBC 患者预后的指标。
关键词：
乳腺肿瘤
癌，基底细胞
缺氧诱导因子1，α 亚基
葡萄糖转运体1 型
Expression and significance of HIF-1α and Glut-1 in basal-like breast carcinoma
CorrespondingAuthor:ZHANG Jinku Email: zjkblk@sohu.com
Abstract
Objective: To investigate the expression and clinical significance of hypoxia inducible factors 1α (HIF-1α) and glucose transporter 1 (Glut-1) in basal-like breast carcinoma (BLBC). Methods: The protein expressions of HIF-1α and Glut-1 in 95 specimens of BLBC and their adjacent breast tissue, and 708 samples of non-BLBC tissue were detected by immunohistochemical staining, and their relations with the clinicopathologic factors of BLBC were analyzed. Results: The positive expression rate of either HIF-1α or Glut-1 protein in BLBC tissue was significantly higher than that in adjacent breast tissue and non-BLBC tissue (all P<0.05), and both HIF-1α and Glut- 1 protein expressions were associated with lymph node metastasis and clinical stage of BLBC (all P<0.05); there was a significantly positive correlation between HIF-1α and Glut-1 expression in BLBC tissue (r=0.368, P<0.05). Conclusion: HIF-1α and Glut-1 synchronously overexpress in BLBC tissue, which may co-participate in the occurrence and development of BLBC, and can be potentially used as a prognostic index for BLBC patients.
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