文章摘要

白细胞介素6 与消化道肿瘤关系的研究进展

作者: 1陈惟, 1卢绮萍
1 广州军区武汉总医院 普通外科，湖北 武汉 430070
通讯: 卢绮萍 Email: ptwklqp111@163.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2015.10.021

摘要

富含炎症细胞、细胞因子、趋化因子的炎症微环境可诱发细胞的增殖和突变，从而为肿瘤细胞的生长、扩散以及免疫逃避提供了可能。白细胞介素6（IL-6）是一种由免疫细胞产生的多功能炎性细胞因子，它在机体炎症反应，免疫应答以及造血调控中都扮演着重要角色。现在越来越多的研究发现肿瘤炎症微环境中的IL-6 在许多肿瘤的发生发展中都起着关键作用，笔者就近年来IL-6 与消化道肿瘤关系的研究进展进行综述。
关键词： 胃肠肿瘤 炎症 白细胞介素6 综述文献

Relationship between interleukin-6 and digestive tract tumors: recent advances

Authors: 1CHEN Wei, 1LU Qiping
1 Department of General Surgery, Wuhan General Hospital of Guangzhou Military, Wuhan 430070, China

CorrespondingAuthor:LU Qiping Email: ptwklqp111@163.com

Abstract

The inflammatory microenvironment that is enriched with inflammatory cells, cytokines and chemokines can induce cell proliferation and mutation, and thereby provides possibility of growth, migration and immune evasion for tumors. Interleukin-6 (IL-6) is a multifunctional inflammatory factor produced by immune cells, which plays an important role in the inflammatory reactions, immune responses and hematopoietic regulation. More and more studies have found that IL-6 plays a key role in the development and progression of many cancers. In this paper, the authors address the recent progress concerning the relationship between IL-6 and digestive tract tumors.
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