Objective: To investigate the application value of Mammotome rotation cutting in treatment of deep breast abscess. Methods: Eighty-one patients with deep breast abscess admitted from October 2010 to January 2015 were selected. Of the patients, 35 cases underwent catheter drainage via ultrasound-guided Mammotome procedure (observational group), and 46 cases were subjected to traditional incision and drainage (control group). The relevant surgical variables, degree of patient’s satisfaction, recurrence rate and postoperative complications between the two groups of patients were compared. Results: The surgical variables that included operative time, intraoperative blood loss, healing time, postoperative scar length, and pain NRS score in observational group were significantly superior to those in control group (all P<0.05). During the period of 3- to 6-month follow-up, in observational group, the degree of patient’s satisfaction was significantly better than that in control group (85.71% vs. 58.33%, P<0.05), and the recurrence rate and incidence of postoperative complications were significantly lower than those in control group (2.86% vs. 19.57%; 5.71% vs. 28.26%, both P<0.05). Conclusion: Mammotome rotation cutting for deep breast abscess has the advantages of minimal invasiveness, fast postoperative recovery, favorable cosmetic results, lower incidence of complications and with higher degree of patient’s satisfaction. So it is recommended to be used in clinical practice.