Objective: To investigate the clinical efficacy and value of using radiofrequency coagulation device in liver resection. Methods: The clinical data of 108 patients undergoing hepatectomy from July 2011 to July 2013 were retrospective analyzed. Of the patients, 41 cases underwent radiofrequency-assisted liver transection (observational group), and 67 cases underwent liver transection using conventional clamp technique (control group). The clinical variables between the two groups were compared. Results: In observational group compared with control group, the operative time, intraoperative blood loss, and the percentage of cases requiring blood transfusion and hepatic portal occlusion were reduced, the values of postoperative transaminase and bilirubin were decreased, the volume of postoperative peritoneal drainage and length of hospital stay were decreased, and all the differences reached statistical significance (all P<0.05). There was no statistical difference in incidence of postoperative complications and hospitalization costs between the two group (both P>0.05). Conclusion: The use of radiofrequency coagulation in liver resection can effectively control blood loss and decrease liver damage and length of hospital stay, and does not increase medical expenses, so it can valuably be applied in hepatectomy.