Objective: To investigate the short- to mid-term clinical efficacy of endovascular intervention for spontaneous isolated superior mesenteric artery dissection (SISMAD). Methods: The clinical data of 16 patients with SISMAD treated from March 2009 to August 2016 were retrospectively analyzed. Of the patients, the dissection was classified as type I in 3 cases (18.75%), type II in 3 cases (18.75%) and type III in 10 cases (62.5%) according to Sakamoto’s classification. Results: One type I patient underwent conservative treatment with satisfactory results, 2 type I patients, 3 type II patients and 5 type III patients underwent single-stent implantation, and 5 type III patients underwent double-stent implantation (one type III case with nearly 95% stenosis in the true lumen had balloon dilation before placement of two stents). All the stents used were self-expanding type. Follow-up was conducted for 1 month to 34 months with a median follow-up time of 16 months, no disease-associated abdominal pain was noted, and CTA showed no flow of contrast in the false lumen and no stent migration or deformation and intra-stent stenosis or occlusion occurred. Conclusion: Endovascular intervention offers favorable short- to mid-term results in treatment SISMAD and however, its long-term outcomes should be further determined.