Objective: To investigate the application value of LigaSure vessel sealing system in surgery for benign thyroid diseases. Methods: The clinical data of 278 patients undergoing surgical treatment for benign thyroid disease from June 2012 to June 2014 were retrospectively analyzed. According to whether using LigaSure or not during surgery, the patients were divided into LigaSure group (130 cases) and traditional surgery group (148 cases). The main clinical variables between the two groups of patients were compared. Results: There was no statistical difference in preoperative general data between the two groups (all P>0.05). In LigaSure group compared with traditional surgery group, the scope of surgical resection showed no significant difference (P>0.05), the operative time was significantly shortened (55.2 min vs. 70.8 min, P<0.05), the intraoperative blood loss was significantly reduced (18.1 mL vs. 35.2 mL, P<0.05), and the incidence of main postoperative complications as well as length of hospitalization had no significant difference (all P>0.05). Conclusion: LigaSure can simplify the surgical procedure, and reduce the operative time and intraoperative bleeding in surgery for benign thyroid diseases. So, it is recommended to be used in clinical practice.