文章摘要

胰腺混合性腺泡- 神经内分泌癌1 例报道及文献复习

作者: 1荣华, 1李民, 1王思珍, 1申荣喜, 1朱道俊, 1王新波
1 南京大学医学院附属金陵医院/ 中国人民解放军南京军区南京总医院 普通外科研究所，江苏 南京 210002
通讯: 王新波 Email: wxinbo@hotmail.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2016.03.018

摘要

目的：探讨胰腺混合性腺泡- 神经内分泌癌（MANEC）的临床病理特征、鉴别诊断和治疗方法。方法：回顾性分析收治的1 例胰腺MANEC 患者的临床资料，结合国内外文献，总结该病的临床特点、病理特征、鉴别诊断和治疗方法。结果：该患者术前影像学检查提示十二指肠降部肿瘤，行手术治疗，术后病理提示胰腺MANEC。术后患者顺利出院，20 个月后复查CT 提示肿瘤无复发转移。结论：胰腺MANEC 是非常罕见的肿瘤，常无典型的症状，最终需要病理确诊。预后至今不清楚，但是早期的手术治疗能显著提高总的生存期。
关键词： 胰腺肿瘤/ 诊断 癌，神经内分泌 病例报告

Mixed acinar-neuroendocrine carcinoma of the pancreas: a case report and literature review

Authors: 1RONG Hua, 1LI Min, 1WANG Sizhen, 1SHEN Rongxi, 1ZHU Daojun, 1WANG Xinbo
1 Affiliated Jinling Hospital, School of Medicine, Nanjing Univeristy/Research Institute of General Surgery, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

CorrespondingAuthor:WANG Xinbo Email: wxinbo@hotmail.com

Abstract

Objective: To investigate the clinicopathologic features, and differential diagnosis and treatment method of the mixed acinar-neuroendocrine carcinoma (MANEC) of the pancreas. Methods: The clinical record of one patient with MANEC was retrospectively analyzed, in combination with domestic and foreign literature review, to summarize the clinical features, pathological features, differential diagnosis and treatment method for this disease. Results: Preoperative imaging examinations suggested that the patient had a tumor of descending duodenum, and then the patient underwent surgical treatment. The pathological diagnosis was pancreatic MANEC. The patient was discharged after operation and no tumor recurrence or metastasis was noted 20 months later. Conclusion: MANEC of the pancreas is extremely rare, usually without typical symptoms, and the final diagnosis depends on pathological findings. Its prognosis remains unclear to date, but early surgical treatment can significantly improve the overall survival.
Keywords：